منابع مشابه
Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
INTRODUCTION Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays. MATERIALS AND METHODS A comprehensive lit...
متن کاملEditorial: The Macroprolactin Problem
Human prolactin (PRL) is synthesized as a prehormone with a molecular weight of 26,000 kDa. When the preprolactin is cleaved, the resulting polypeptide has a molecular weight of 23,000 kDa, and this monomeric form accounts for the majority of total PRL. Serum also contains a 50,000-kDa form that is termed big PRL and another species with a molecular weight of greater than l00,000 kDa, which is ...
متن کاملMacroprolactin and hyperprolactinaemia.
The recent report on “macroprolactin and hyperprolactinaemia” is very interesting. Jamaluddin et al. noted that 4.4 % of the patients have macroprolactin and concluded that “macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment.” Similar to many other “macro” phenomenon (macroCK, macroamylase, etc.), the macroprolactin can result in aberra...
متن کاملmacroprolactin; a frequent cause of misdiagnosed hyperprolactinemia in clinical practice
introduction: macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. its frequency has not been clearly established due to technical difficulties in identifying it. most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays. materials and methods: a comprehensive lit...
متن کاملClinical Relevance of Adipokines
The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines) changes towards a pro-inflammatory, diabetogenic and atherogenic pattern. Adipokines are involved in the regu...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2005
ISSN: 0300-0664,1365-2265
DOI: 10.1111/j.1365-2265.2005.02243.x